In-vitro Biologist (Scientist) - Job description

About Us

We are an early-stage start up unlocking the next generation of molecular glues by utilising our unique computational platform. We have several active programs spanning a range of mechanisms and disease areas. We are headquartered in London, with laboratory facilities in Stevenage.

Your Profile

We are looking for intellectually curious and driven biologists who are passionate about unlocking the next generation of small molecule therapeutics. You would thrive in a dynamic start-up environment, working on multiple projects simultaneously and enjoying the challenge of solving complex problems. You’re motivated to make impactful contributions to research in targeted protein degradation and induced proximity.

Your Role

• Join the Drug Discovery Team in Stevenage, reporting to a biology Principal Scientist

• This is a lab-based role working at our research facility in the Stevenage Bioscience Catalyst (SBC) on the GSK Campus 

• Access to excellent on-site amenities including a gym, coffee shop, restaurant, and shuttle-bus to Stevenage train station

• Develop and run bespoke cellular assays to characterise the pharmacology of key molecular glue compounds.

• Work closely with our drug discovery and computational scientists to provide novel experimental data to improve the TernaryTx platform and internal projects

• Present your data during internal team meetings including to non-expert audiences

• Ensure smooth running of the lab

• managing reagents and consumables

• maintenance of cell lines with excellent aseptic technique

• Management of internal compound handling and inventory, working closely with the chemistry team to ensure samples are solubilised and available for internal screening

Requirements

Essential Qualifications

• BSc./MSc. in biology/biochemistry/pharmacology/molecular biology (or equivalent experience) 

• Direct experience in drug discovery gained through industrial placements/internships within biotech, the pharmaceutical industry, or CROs (minimum 2+ years)  

• Previous experience with some of the following techniques 

• cell culture with excellent aseptic technique 

• running plate-based assays (e.g. luminescence/fluorescence based assays, ELISA, high-content imaging etc) in 96 and 384 well formats

• protein characterisation (Western blot, SDS Page, flow cytometry) 

• molecular biology techniques (e.g. PCR, qPCR) 

• Work safely, adhering to health and safety guidelines, risk assessments, and SOPs 

• Strong data handling skills including 

• manipulation of data and the use of common spreadsheet functions (in Google Sheets or Excel) 

• use of GraphPad Prism 

• Self-motivated team player with excellent communication, organisational, and interpersonal skills

• Right to work in the UK

Preferred (Non-Essential) Skills

• Familiar with basic lab automation for liquid handling 

• Previous experience working with modern ELN systems such as CDD Vault or Dotmatics 

• Experience working in any of the following areas

• inflammation

• neurodegeneration / CNS drug discovery 

• targeted protein degradation / induced proximity

• Familiarity with biophysical techniques including

• protein expression / purification 

• SPR