Synthetic Medicinal Chemist (Scientist)
- Job description

About Us

We are an early-stage start up unlocking the next generation of molecular glues by utilising our unique computational platform. We have several active programs spanning a range of mechanisms and disease areas. We are headquartered in London, with laboratory facilities in Stevenage.

Your Profile

We are looking for intellectually curious and driven synthetic medicinal chemists who are passionate about unlocking the next generation of small molecule therapeutics. You would thrive in a dynamic start-up environment, working on multiple projects simultaneously and enjoying the challenge of solving complex problems. You’re motivated to make impactful contributions to research in AI-enabled targeted protein degradation and induced proximity.

Your Role

Join the Drug Discovery Team in London, reporting to the Head of Drug Discovery, Adam Yip
Help to advance our molecular glue discovery projects

Contribute to the design and optimisation of novel compounds across multiple therapeutic projects.
Lead external synthetic efforts at CROs, including troubleshooting of synthetic routes and analysis of QC data, ensuring accurate record keeping to support future publications and patents
Work closely with our computational scientists to develop and apply the TernaryTx platform to projects, and provide expert feedback to improve our products

Manage our compound registration and logistics processes across four locations and work closely with our internal biology team to make sure compounds are available for assays in a timely manner
Hybrid working between our London and Stevenage offices (at least 3 days/week for the first 6 months while you get up to speed)
- This is primarily a desk-based role. TernaryTx currently outsource all of our synthetic chemistry

Requirements

Essential Qualifications

BSc/MSc./MSci./MChem. in chemistry / medicinal chemistry / chemical sciences (or equivalent experience)
Direct experience in drug discovery gained through industrial placements/internships/CASE awards within biotech, the pharmaceutical industry, or CROs
Strong understanding of modern synthetic and heterocyclic chemistry including previous hands-on experience in multistep synthesis
Understanding of core concepts for medicinal chemistry including

SAR analysis (on-target activity, selectivity, matched-molecular pairs etc)
ADME properties and their applications in molecular design

Strong data handling skills including

manipulation of long/wide format data and the use of common spreadsheet functions (in Google Sheets or Excel)
understanding of database-like structures and relationships
experience working with chemical data formats (e.g. SMILES, InChi, SDfiles etc)

Self-motivated team player with excellent communication, organisational, and interpersonal skills
Right to work in the UK

Preferred (Non-Essential) Skills

Previous experience working with modern ELN systems such as CDD Vault or Dotmatics
Previous experience of outsourcing work to contract research organisations
Experience working in any of the following areas